Anti-DKK1 Monoclonal Antibody BHQ880

Preferred Label : Anti-DKK1 Monoclonal Antibody BHQ880;

NCIt related terms : BHQ-880; BHQ880;

NCIt definition : A humanized monoclonal antibody directed against Wnt antagonist Dickkopf-1 (DKK1) with potential anti-osteolytic activity. Anti-DKK1 monoclonal antibody BHQ880 binds to and inhibits DKK1, enhancing signaling through the Wnt pathway, which may result in osteoblast differentiation and activation within the bone matrix and the reversal of tumor-induced osteolytic disease. DKK1 is a potent Wnt signaling pathway antagonist.;

UNII : IS3ESI44W5;

Molecule name : BHQ-880;

Codes from synonyms : 57;

Details

Origin ID

C80040;

UMLS CUI

C2703201;

Currated CISMeF NLP mapping
- BHQ880 [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- BHQ880 [MeSH concept]
- BHQ880 [MeSH Supplementary Concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Dickkopf-Related Protein 1 [NCIt concept]

Keyword's position in hierarchy(ies) :

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