Sotatercept - CISMeF

Preferred Label : Sotatercept;

NCIt synonyms : Decoy Activin Receptor ACE-011;

NCIt definition : A soluble fusion protein composed of the extracellular domain of the activin receptor type IIA (ActRIIA) linked to the Fc portion of human IgG1 with anabolic bone activity. Sotatercept selectively binds to activin, inhibiting its binding to ActRIIA and ActRIIA signaling, resulting in the stimulation of osteoblast activity and the inhibition of osteoclast activity and so normal bone formation and increased bone mineral density and strength. The Fc moiety of this fusion protein binds to the salvage receptor FcRN, preventing its lysosomal degradation and so extending its half-life in the circulatory system.;

UNII : 0QI90BTJ37;

CAS number : 1001080-50-7;

Molecule name : ACE-011;

Details

Origin ID

C80038;

UMLS CUI

C2699571;

Automatic exact mappings (from CISMeF team)
- ACE-011 [MeSH Supplementary Concept]
Currated CISMeF NLP mapping
- Sotatercept [SMS substance]
- sotatercept [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- sotatercept [MeSH concept]
Validated automatic mappings to BTNT
- ACE-011 [MeSH concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_target
- Activin Receptor Type-2A [NCIt concept]

Keyword's position in hierarchy(ies) :

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