NCIt definition : A soluble fusion protein composed of the extracellular domain of the activin receptor
type IIA (ActRIIA) linked to the Fc portion of human IgG1 with anabolic bone activity.
Sotatercept selectively binds to activin, inhibiting its binding to ActRIIA and ActRIIA
signaling, resulting in the stimulation of osteoblast activity and the inhibition
of osteoclast activity and so normal bone formation and increased bone mineral density
and strength. The Fc moiety of this fusion protein binds to the salvage receptor FcRN,
preventing its lysosomal degradation and so extending its half-life in the circulatory
system.;
UNII : 0QI90BTJ37;
CAS number : 1001080-50-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1001080-50-7
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;