Fadrozole - CISMeF

Preferred Label : Fadrozole;

NCIt synonyms : 4-(5,6,7,8-Tetrahydroimidazo(1,5-a)pyridin-5-yl)benzonitrile; ( /-)-p-(5,6,7,8-Tetrahydroimidazo(1,5-a)pyridin-5-Yl)benzonitrile;

NCIt definition : A nonsteroidal aromatase inhibitor fadrozole with potential antineoplastic activity. Fadrozole specifically inhibits aromatase, blocking the aromatization of androstenedione and testosterone into estrone and estradiol, respectively, the final step in estrogen biosynthesis; the reduction in estrogen levels may inhibit growth in estrogen-dependent cancers. Aromatase, a member of the cytochrome P-450 superfamily, is found in many tissues; overexpression has been linked to the development of preneoplastic and neoplastic changes in breast tissue.;

UNII : H3988M64PU;

InChIKey : CLPFFLWZZBQMAO-UHFFFAOYSA-N;

CAS number : 102676-47-1;

Chemical formula : C14H13N3;

Codes from synonyms : 122313;

Details

Origin ID

C79911;

UMLS CUI

C0117234;

Currated CISMeF NLP mapping
- fadrozole [MeSH Descriptor]
- fadrozole [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- fadrozole [MeSH concept]
- fadrozole [MeSH Descriptor]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
has_salt_form
- Fadrozole Hydrochloride [NCIt concept]
is_free_acid_or_base_form_of
- Fadrozole Hydrochloride [NCIt concept]

Keyword's position in hierarchy(ies) :

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