Preferred Label : Fadrozole Hydrochloride;
NCIt synonyms : 4-(5,6,7,8-Tetrahydroimidazo(1,5-a)pyridin-5-yl)benzonitrile Hydrochloride;
NCIt related terms : 4-(5,6,7,8-Tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile Monohydrochloride;
NCIt definition : The hydrochloride salt of the nonsteroidal aromatase inhibitor fadrozole with potential
antineoplastic activity. Fadrozole specifically inhibits aromatase, blocking the aromatization
of androstenedione and testosterone into estrone and estradiol, respectively, the
final step in estrogen biosynthesis; the reduction in estrogen levels may inhibit
growth in estrogen-dependent cancers. Aromatase, a member of the cytochrome P-450
superfamily, is found in many tissues; overexpression has been linked to the development
of preneoplastic and neoplastic changes in breast tissue.;
UNII : H0Q44H4ECQ;
InChIKey : UKCVAQGKEOJTSR-UHFFFAOYSA-N;
CAS number : 102676-31-3; 102676-96-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 102676-31-3
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G-SRS /a ; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 102676-96-0
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G-SRS /a ;
Drug name : Arensin; Afema;
Molecule name : CGS-16949A;
Chemical formula : C14H13N3.HCl;
Codes from synonyms : 08932;
Origin ID : C1044;
UMLS CUI : C0917743;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to NTBT
- concept_is_in_subset
- has_free_acid_or_base_form
- is_salt_form_of
