Preferred Label : Elesclomol Sodium;
NCIt synonyms : 1-N'-benzenecarbothioyl-3-(2-benzenecarbothioyl-2-methylhydrazinyl)-N'-methyl- oxopropanehydrazidide
Sodium; Propanedioic Acid, Bis[2-methyl-2-(phenylthioxomethyl)hydrazide], Sodium Salt;
NCIt definition : The water soluble sodium salt of a small-molecule bis(thio-hydrazide amide) with oxidative
stress induction, pro-apoptotic, and potential antineoplastic activities. Elesclomol
induces oxidative stress, creating high levels of reactive oxygen species (ROS), such
as hydrogen peroxide, in both cancer cells and normal cells. Because tumor cells have
elevated levels of ROS compared to normal cells, the increase in oxidative stress
beyond baseline levels elevates ROS beyond sustainable levels, exhausting tumor cell
antioxidant capacity, which may result in the induction of the mitochondrial apoptosis
pathway. Normal cells are spared because the increase in the level of oxidative stress
induced by this agent is below the threshold at which apoptosis is induced.;
Alternative definition : NCI-GLOSS: A drug used in the treatment of skin cancer that has spread. It is also
being studied in the treatment of other types of cancer. It increases the amount of
harmful oxygen molecules in cells and may kill cancer cells. It may also help other
drugs kill cancer cells. It is a type of oxidative stress inducer.;
UNII : L219C7807V;
InChIKey : SEWIXCGFJQCKPA-UHFFFAOYSA-L;
CAS number : 874477-51-7;
Molecule name : STA-4783;
Codes from synonyms : CDR0000648987;
Origin ID : C79840;
UMLS CUI : C2699865;
Semantic type(s)
- concept_is_in_subset
- has_free_acid_or_base_form
- is_salt_form_of
