NCIt definition : A small-molecule bis(thio-hydrazide amide) with oxidative stress induction, pro-apoptotic,
and potential antineoplastic activities. Elesclomol induces oxidative stress, creating
high levels of reactive oxygen species (ROS), such as hydrogen peroxide, in both cancer
cells and normal cells. Because tumor cells have elevated levels of ROS compared to
normal cells, the increase in oxidative stress beyond baseline levels elevates ROS
beyond sustainable levels, exhausting tumor cell antioxidant capacity, which may result
in the induction of the mitochondrial apoptosis pathway. Normal cells are spared because
the increase in the level of oxidative stress induced by this agent is below the threshold
at which apoptosis is induced.;
UNII : 6UK191M53P;
InChIKey : BKJIXTWSNXCKJH-UHFFFAOYSA-N;
CAS number : 488832-69-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 488832-69-5
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;