Hsp90 Inhibitor XL888

Preferred Label : Hsp90 Inhibitor XL888;

NCIt synonyms : Heat Shock Protein 90 Inhibitor XL888;

NCIt related terms : XL-888;

NCIt definition : An orally bioavailable, ATP-competitive, small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. Hsp90 inhibitor XL888 specifically binds to Hsp90, inhibiting its chaperone function and promoting the proteasomal degradation of oncogenic signaling proteins involved in tumor cell proliferation and survival; inhibition of tumor cell proliferation may result. Hsp90, a chaperone complex protein upregulated in a variety of tumor cell types, regulates the folding and degradation of many oncogenic signaling proteins, including Her-2 and Met.;

UNII : 7M346920EV;

CAS number : 1149705-71-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1149705-71-4 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : XL-888;

NCI Metathesaurus CUI : CL388445;

Details

Origin ID

C79835;

UMLS CUI

C3177388;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- XL 888 [MeSH concept]
- XL 888 [MeSH Supplementary Concept]
chemical_or_drug_has_physiologic_effect
- Positive Regulation of Apoptosis [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Heat Shock Protein 90 [NCIt concept]

Keyword's position in hierarchy(ies) :

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