Preferred Label : Sonolisib;
NCIt synonyms : acetic acid 4-diallylaminomethylene-6-hydroxy-1-alpha 12-methoxymethyl-10beta,13beta-dimethyl-3,7,17-trioxo-1,3,4,7,10,11beta,12,13,14alpha,15,16,17-dodecahydro-2-oxa-cyclopenta[a]phenanthren-11-yl
ester; (4E)-4-(((Bis(prop-2-en-1-yl)amino)methylidene)-6-hydroxy-1alpha-(methoxymethyl)-3,7,17-trioxo-2-oxaandrosta-5,8-dien-11alpha-yl
Acetate; acetic acid (1S,4E,10R,11R,13S,14R)-4-diallylaminomethylene-6-hydroxy-1-methoxymethyl-10,13-dimethyl-3,7,17-trioxo-1,3,4,7,10,11,12,13,14,15,16,17-dodecahydro-2-oxa-cyclopenta[a]phenanthren-11-yl
ester; PI3K Inhibitor PX-866;
NCIt definition : A small-molecule wortmannin analogue inhibitor of the alpha, gamma, and delta isoforms
of phosphoinositide 3-kinase (PI3K) with potential antineoplastic activity. Sonolisib
inhibits the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate
(PIP3) and activation of the PI3K/Akt signaling pathway, which may result in inhibition
of tumor cell growth and survival in susceptible tumor cell populations. Activation
of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and
dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of
antineoplastic agents.;
UNII : 987796874T;
InChIKey : QIUASFSNWYMDFS-NILGECQDSA-N;
CAS number : 502632-66-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 502632-66-8
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Molecule name : PX-866; PX 866;
Origin ID : C78848;
UMLS CUI : C4317116;
Automatic exact mappings (from CISMeF team)
- acetic acid (1S,4E,10R,11R,13S,14R)-(4-diallylaminomethylene-6-hydroxy-1-methoxymethyl-10,13-dimethyl-3,7,17-trioxo-1,3,4,7,10,11,12,13,14,15,16,17-dodecahydro-2-oxa-cyclopenta(a)phenanthren-11-yl)ester [MeSH concept]
- See also inter- (CISMeF)
- PX-866 [MeSH Supplementary Concept]
- Semantic type(s)
- concept_is_in_subset
- has_target
