Hsp90 Inhibitor BIIB028

Preferred Label : Hsp90 Inhibitor BIIB028;

NCIt synonyms : Hsp90 Inhibitor BIIB02;

NCIt related terms : BIIB-028;

NCIt definition : A small-molecule inhibitor of heat shock protein (Hsp) 90 with potential antineoplastic activity. Hsp90 inhibitor BIIB028 blocks the binding of oncogenic client proteins to Hsp90, which may result in the proteasomal degradation of these proteins and so the inhibition of tumor cell proliferation. Hsp90 is a molecular chaperone that plays a key role in the conformational maturation of oncogenic signaling proteins, such as Her2/Erbb2, Akt, Raf1, Bcr-Abl, and mutated p53, in addition to other molecules involved in cell cycle regulation and immune responses.;

UNII : KD4GWWK597;

CAS number : 911398-13-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 911398-13-5 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : BIIB028;

NCI Metathesaurus CUI : CL387614;

Details

Origin ID

C78846;

UMLS CUI

C2703139;

Semantic type(s)
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_has_physiologic_effect
- Positive Regulation of Apoptosis [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Heat Shock Protein 90 [NCIt concept]

Keyword's position in hierarchy(ies) :

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