Oral Hsp90 Inhibitor IPI-493

Preferred Label : Oral Hsp90 Inhibitor IPI-493;

NCIt synonyms : Heat Shock Protein 90 Inhibitor IPI-493; 17-Aminogeldanamycin; 17-Aminodemethoxygeldanamycin; Hsp90 Inhibitor IPI-493;

NCIt related terms : IPI-493;

NCIt definition : An orally bioavailable formulation of the ansamycin derivative 17-amino-17-demethoxygeldanamycin (17-AG) with potential antineoplastic activity. Oral Hsp90 inhibitor IPI-493 binds to and inhibits Hsp90, which may result the in growth inhibition in sensitive tumor cell populations. Hsp90, a 90 kDa molecular chaperone, may be highly expressed in tumor cells, playing a key role in the conformational maturation, stability and function of other substrate or client proteins within the cell; many of these client proteins are involved in signal transduction, cell cycle regulation and apoptosis, and may include kinases, transcription factors and hormone receptors.;

UNII : SLQ1AJG3VB;

CAS number : 64202-81-9;

Molecule name : IPI-493;

NSC code : 255109;

Details

Origin ID

C78843;

UMLS CUI

C2697619;

Automatic exact mappings (from CISMeF team)
- 17-aminogeldanamycin [MeSH Supplementary Concept]
- 17-aminogeldanamycin [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_has_physiologic_effect
- Positive Regulation of Apoptosis [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Heat Shock Protein 90 [NCIt concept]

Keyword's position in hierarchy(ies) :

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