" /> Oral Hsp90 Inhibitor IPI-493 - CISMeF





Preferred Label : Oral Hsp90 Inhibitor IPI-493;

NCIt synonyms : Heat Shock Protein 90 Inhibitor IPI-493; 17-Aminogeldanamycin; 17-Aminodemethoxygeldanamycin; Hsp90 Inhibitor IPI-493;

NCIt related terms : IPI-493;

NCIt definition : An orally bioavailable formulation of the ansamycin derivative 17-amino-17-demethoxygeldanamycin (17-AG) with potential antineoplastic activity. Oral Hsp90 inhibitor IPI-493 binds to and inhibits Hsp90, which may result the in growth inhibition in sensitive tumor cell populations. Hsp90, a 90 kDa molecular chaperone, may be highly expressed in tumor cells, playing a key role in the conformational maturation, stability and function of other substrate or client proteins within the cell; many of these client proteins are involved in signal transduction, cell cycle regulation and apoptosis, and may include kinases, transcription factors and hormone receptors.;

UNII : SLQ1AJG3VB;

CAS number : 64202-81-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 64202-81-9 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : IPI-493;

NSC code : 255109;

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14/05/2024


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