NCIt synonyms : Durie/Salmon Stage III Plasma Cell Myeloma; Stage III Multiple Myeloma; Stage III Plasma Cell Myeloma; DS Stage III Plasma Cell Myeloma; Multiple Myeloma Stage III; Durie/Salmon Stage III Multiple Myeloma;
NCIt related terms : DS Stage III Multiple Myeloma/Plasma Cell Myeloma;
NCIt definition : Multiple myeloma with one or more of the following: 1. Hemoglobin less than 8.5 g/dL.
2. Serum calcium greater than 12.0 mg/dL. 3. More than three lytic bone lesions. 4.
High M protein production as shown by: a. IgG greater than 7.0 g/dL. b. IgA greater
than 5.0 g/dL. c. Urinary kappa or lamda greater than 12.0 g/24 hours. Estimated myeloma
cell mass: greater than 1.2 trillion (1012)/m2 (high burden). The following subclassification
of stages is used: a. Creatinine less than 2.0 mg/dL. b. Creatinine greater than or
equal to 2.0 mg/dL. Serum beta-2-microglobulin has been shown to be a reliable marker
for prognosis. Since the great majority of symptomatic myeloma patients are classified
as stage III by the Durie/Salmon criteria, this staging system has not proven to be
very useful for identifying the patients with intermediate and poor prognosis. Note
that the newer International Staging System defines stage III quite differently: Beta-2-microglobulin
greater than or equal to 5.5 (median survival of 29 months). (PDQ);
Alternative definition : NCI-GLOSS: A relatively large number of cancer cells have spread throughout the body.
There may be one or more of the following: 1) a decrease in the number of red blood
cells, causing anemia; 2) the amount of calcium in the blood is very high, because
the bones are being damaged; 3) more than three bone tumors (plasmacytomas) are found;
or 4) high levels of M protein are found in the blood or urine.;