NCIt synonyms : Durie/Salmon Stage I Plasma Cell Myeloma; Durie/Salmon Stage I Multiple Myeloma; Stage I Plasma Cell Myeloma; DS Stage I Plasma Cell Myeloma; Multiple Myeloma Stage I;
NCIt related terms : DS Stage I Multiple Myeloma/Plasma Cell Myeloma; stage I multiple myeloma;
NCIt definition : Multiple myeloma with all of the following: 1. Hemoglobin greater than 10 g/Dl, 2.
Normal serum calcium, 3. Normal bone structure, 4. Low monoclonal (or myeloma) protein
(M protein) production as shown by: a. IgG less than 5.0 g/dL, b. IgA less than 3.0
g/dL, c. Urinary kappa or lamda less than 4 g/24 hours. Estimated myeloma cell mass:
less than 0.6 trillion (1012)/m2 (low burden). The following subclassification of
stages is used: a. Creatinine less than 2.0 mg/dL, b. Creatinine greater than or equal
to 2.0 mg/dL. Impaired renal function worsens prognosis regardless of stage. Note
that the newer International Staging System defines stage I quite differently: Beta-2-microglobulin
less than 3.5 and albumin greater than or equal to 3.5 (median survival of 62 months).
(PDQ);
Alternative definition : NCI-GLOSS: Relatively few cancer cells have spread throughout the body. There may
be no symptoms of disease.;