" /> Tigapotide - CISMeF





Preferred Label : Tigapotide;

NCIt synonyms : Prostate-Secretory Protein-94-Derived Peptide PCK3145; PSP-94-Derived Synthetic Peptide PCK3145;

NCIt definition : A synthetic 15-mer peptide corresponding to amino acids 31-45 of the 94-amino acid isoform of human prostate secretory protein (PSP-94) with potential anti-metastasis and anti-angiogenesis activities. PSP-94-derived peptide PCK3145 may inhibit the secretion of the metastasis-related protein matrix metalloproteinase-9 (MMP-9) and its potential binding to its cell surface receptor CD44; may interfere with the vascular endothelial growth factor (VEGF) signaling pathway, resulting in an anti-angiogenesis effect; and may reduce the levels of parathyroid hormone-related protein (PTHrP), decreasing plasma calcium levels. PSP-94, one of three predominant proteins found in seminal fluid, may be down-regulated in prostate cancer, representing a potential survival mechanism for prostate cancer cells. MMP-9 is implicated in the invasion and metastasis of cancer. PTHrP may be expressed by various tumor cell types, resulting in the hypercalcemia of malignancy.;

UNII : 1WZ6S45S94;

InChIKey : ZRXXHPDJLAQCPC-SFJRRRFZSA-N;

CAS number : 848084-83-3; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 848084-83-3 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : PCK3145;

Chemical formula : C82H119N21O34S3;

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15/05/2024


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