Preferred Label : PI3K Inhibitor GSK1059615;
NCIt related terms : GSK-1059615;
NCIt definition : A phosphoinositide 3-kinase (PI3K) inhibitor with potential antineoplastic activity.
PI3K inhibitor GSK1059615 inhibits PI3K in the PI3K/AKT kinase signaling pathway,
which may trigger the translocation of cytosolic Bax to the mitochondrial outer membrane
and an increase in mitochondrial membrane permeability, followed by apoptosis. Bax
is a member of the proapoptotic Bcl-2 family of proteins. PI3K, an enzyme often overexpressed
in cancer cells, plays a crucial role in tumor cell regulation and survival.;
UNII : 07YMO87363;
CAS number : 958852-01-2;
Molecule name : GSK1059615;
NCI Metathesaurus CUI : CL387567;
Origin ID : C78470;
UMLS CUI : C2698693;
Semantic type(s)
- concept_is_in_subset
- has_target
