Preferred Label : Talactoferrin Alfa;
NCIt synonyms : Oral Recombinant Human Lactoferrin; Oral rhLF;
NCIt related terms : TLF; talactoferrin;
NCIt definition : An orally bioavailable recombinant human lactoferrin produced in the fungus Aspergillus
niger with potential antineoplastic and immunomodulating activities. Upon oral administration,
talactoferrin is transported into small intestinal Peyer's patches of the gut-associated
lymphoreticular tissues (GALT), where it recruits circulating immature dendritic cells
(DCs) bearing tumor antigens and induces their maturation. In the GALT, DC maturation
in the presence of tumor antigens and lymphoid effector cells may induce systemic
innate and adaptive immune responses mediated by anti-tumor natural killer (NK) cells,
cytotoxic T lymphocytes, and natural killer T (NKT) cells; activation of tumor-draining
lymph nodes, cellular infiltration of distant tumors, and tumor-cell death may follow.
Raising the initial immune response in the GALT, distant from the primary tumor, may
counter local tumor-mediated immunosuppression.;
Alternative definition : NCI-GLOSS: A drug being studied in the treatment of kidney cancer that has spread.
It is also being studied in the treatment of other types of cancer and other conditions.
Talactoferrin increases the activity of dendritic cells (a type of immune cell) to
help kill cancer cells. It is a form of human lactoferrin (a protein found in milk,
tears, mucus, bile, and some white blood cells) that is made in the laboratory. Talactoferrin
is a type of recombinant protein and a type of immunomodulatory protein.;
UNII : 7A055A9QRR;
CAS number : 308240-58-6;
Codes from synonyms : CDR0000642982; CDR0000642985; CDR0000642983;
Origin ID : C78460;
UMLS CUI : C1872514;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
