Preferred Label : Transferrin Receptor-Targeted Anti-RRM2 siRNA CALAA-01;
NCIt synonyms : Transferrin Receptor-Targeted Nanocomplexed Anti-R2 siRNA CALAA-01;
NCIt definition : A proprietary transferrin receptor-targeted nanoparticle preparation of a non-chemically
modified small-interfering RNA (siRNA) directed against the M2 subunit of ribonucleotide
reductase (RRM2) with potential antineoplastic activity. Upon administration, transferrin
receptor-targeted anti-RRM2 siRNA CALAA-01 binds to transferrin receptors (TfRs),
releasing anti-RRM2 siRNA after endocytosis; anti-RRM2 siRNA silences the expression
of RRM2 via the RNAi pathway, impeding the assembly of the holoenzyme ribonucleotide
reductase (RR) which catalyzes the production of deoxyribonucleotides. As a result,
inhibition of cellular proliferation may occur in cells expressing TfR, a cell surface
protein overexpressed on various cancer cell types.;
Molecule name : CALAA-01;
Origin ID : C78450;
UMLS CUI : C2700060;
Semantic type(s)
- concept_is_in_subset
- has_target
