Preferred Label : Glembatumumab Vedotin;
NCIt synonyms : Antibody-Drug Conjugate CR011-vcMMAE; CR011-vcMMAE Immunotoxin;
NCIt definition : An antibody-drug conjugate, consisting of the fully human monoclonal antibody CR011
directed against glycoprotein NMB (GPNMB) and conjugated via a cathepsin B-sensitive
valine-citrulline (vc) linkage to the cytotoxic agent monomethyl auristatin E (MMAE),
with potential antineoplastic activity. Upon administration, the monoclonal antibody
CR011 moiety binds to glycoprotein nmb (GPNMB), expressed on the surfaces of a variety
of cancer cell types; upon endocytosis, the synthetic dolastin analogue MMAE is released
via enzymatic cleavage into the tumor cell cytosol, where it binds to tubulin and
inhibits tubulin polymerization, which may result in G2/M phase arrest and apoptosis.
The vc linkage system is highly stable in serum, rendering the cytotoxicity of glembatumumab
vedotin specific for GPNMB-positive cells. GPNMB is a transmembrane protein overexpressed
on the surfaces of various cancer cell types, including melanoma, breast, and prostate
cancer cells.;
UNII : 1568H6A58U;
CAS number : 1182215-65-1;
Molecule name : CDX-011; CR011-vcMMAE;
Origin ID : C78449;
UMLS CUI : C2935736;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_target
