Aviscumine - CISMeF

Preferred Label : Aviscumine;

NCIt synonyms : Ribosome-Inactivating Protein CY503; Toxin ML-I (Mistletoe Lectin I) (Viscum album);

NCIt definition : A recombinant protein that inactivates the ribosome with potential antineoplastic and immunomodulating activities. Aviscumine binds to the cell surface sialyltransferase CD75 and is internalized; intracellularly, aviscumine cleaves an adenine-specific N-glycosidic bond on the 28S ribosomal subunit, which may result in tumor cell apoptosis. This agent has also been shown to activate natural killer (NK) cells, induce cytokine receptor expression, and stimulate the release of cytokines. CD75 is expressed on mature B-cells and subsets of T-cells and erythrocytes.;

UNII : 4B18YVW82N;

CAS number : 223577-45-5;

Molecule name : CY-503; CY 503;

NCI Metathesaurus CUI : CL383580;

Details

Origin ID

C78188;

UMLS CUI

C1450556;

Automatic exact mappings (from CISMeF team)
- ribosome inactivating protein, Viscum [MeSH Supplementary Concept]
Currated CISMeF NLP mapping
- aviscumine [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- aviscumine [MeSH concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients