NCIt synonyms : Anti-CD70 Fully Human Monoclonal Antibody MDX-1411;
NCIt definition : A glycoengineered, fully human IgG1 monoclonal antibody directed against the extracellular
domain of the human CD70 molecule with potential antineoplastic activity. Anti-CD70
fully human monoclonal antibody MDX-1411 selectivity binds to the extracellular domain
of CD70, which may induce an antibody-dependent cellular cytotoxicity (ADCC) response
against CD70-expressing tumor cells. CD70, the ligand for the costimulatory receptor
CD27 and a member of the tumor necrosis factor (TNF) family, is found on renal cell
carcinoma (RCC) cells among other cancer cell types.;
Semantic type(s)