Propylthiouracil

Preferred Label : Propylthiouracil;

NCIt synonyms : 6-Propyl-2-Thiouracil;

NCIt definition : A thiourea derivative with antithyroid property. Propylthiouracil (PTU) interferes with the oxidation of iodine possibly by interaction with peroxidase or a peroxidase-mediated complex reaction, thereby inhibiting synthesis of thyroid hormones tri-iodothyronine (T3) and thyroxine (T4). In addition, this agent inhibits the Type I 5'-deiodinase (D1), an enzyme involved in the peripheral conversion of thyroxine to tri-iodothyronine. This results in decreased plasma triodothyronine concentrations and decreased entrance of thyroxine into cells thereby reducing thyroid hormone activity.;

UNII : 721M9407IY;

InChIKey : KNAHARQHSZJURB-UHFFFAOYSA-N;

CAS number : 51-52-5;

Chemical formula : C7H10N2OS;

NSC code : 70461;

ChEBI ID : CHEBI:8502;

Codes from synonyms : NSC0070461;

Details

Origin ID

C781;

UMLS CUI

C0033511;

See also inter- (CISMeF)
- Product containing propylthiouracil (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing propylthiouracil (medicinal product) [SNOMED CT concept]
- Propylthiouracil [ICD-11 Extension code]
- Propylthiouracil [LOINC component]
- Propylthiouracil (substance) [SNOMED CT concept]
- propylthiouracil [ATC Code]
- propylthiouracil [Substance BNPC]
- propylthiouracil [MeSH concept]
- propylthiouracil [MeSH Descriptor]
- propylthiouracil preparation [SNOMED Notion]
Validated automatic mappings to BTNT
- propylthiouracil [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients