Methoxyamine Hydrochloride

Preferred Label : Methoxyamine Hydrochloride;

NCIt definition : The hydrochloride salt form of methoxyamine, an alkoxyamine with potential chemotherapeutic adjuvant activity. Methoxyamine covalently binds to apurinic/apyrimidinic DNA damage sites and thereby inhibits base excision repair (BER) process, which may prevent repair of DNA strand breaks and result in an induction of apoptosis. This agent may potentiate the anti-tumor activity of alkylating agents.;

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of cancer. It blocks the ability of a cell to repair damage to its DNA and may kill cancer cells. It may also help some anticancer drugs work better. It is a type of antineoplastic agent.;

UNII : 203546OLMF;

CAS number : 593-56-6;

Molecule name : TRC-102; TRC 102;

Chemical formula : CH5NO.HCl;

NSC code : 3801;

Codes from synonyms : CDR0000648993;

Details

Origin ID

C78085;

UMLS CUI

C0951345;

Automatic exact mappings (from CISMeF team)
- methoxyamine [MeSH Supplementary Concept]
Currated CISMeF NLP mapping
- methoxyamine hydrochloride [MeSH concept]
- methoxyammonium chloride [Substance BNPC]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- methoxyamine hydrochloride [MeSH concept]
- methoxyammonium chloride [Substance BNPC]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_free_acid_or_base_form
- Methoxyamine [NCIt concept]
is_salt_form_of
- Methoxyamine [NCIt concept]

Keyword's position in hierarchy(ies) :

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