NCIt synonyms : 3-(3-Carboxy-3-methyl-1-oxobutoxy)-, (3-beta)-, compd. with 1-deoxy-1-(methylamino)-D-glucitol
(1:2);
NCIt definition : A dimeglumine formulation of bevirimat, a drug derived from a betulinic acid-like
compound, first isolated from the Chinese herb Syzygium claviflorum, with activity
against human immunodeficiency virus (HIV). Bevirimat acts by binding to the Gag capsid
precursor protein and blocking its conversion to mature capsid protein by protease
cleavage. It potently inhibits replication in both wild-type and drug-resistant (reverse
transciptase or protease) HIV-1 isolates.;
Semantic type(s)