Preferred Label : Ganetespib;
NCIt synonyms : Hsp90 Inhibitor STA-9090; 3-(2,4-dihydroxy-5-isopropylphenyl)-4-(1-methylindol-5-yl)-5-hydroxy-4h-1,2,4-triazole
3h-1,2,4-triazol-3-one; 5-(2,4-dihydroxy-5-(1-methylethyl)phenyl)-2,4-dihydro-4-(1-methyl-1h-indol-5-yl)-;
NCIt definition : A synthetic small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential
antineoplastic activity. Ganetespib binds to and inhibits Hsp90, resulting in the
proteasomal degradation of oncogenic client proteins, the inhibition of cell proliferation
and the elevation of heat shock protein 72 (Hsp72); it may inhibit the activity of
multiple kinases, such as c-Kit, EGFR, and Bcr-Abl, which as client proteins depend
on functional HsP90 for maintenance. Hsp90, a 90 kDa molecular chaperone upregulated
in a variety of tumor cells, plays a key role in the conformational maturation, stability
and function of client proteins within the cell, many of which are involved in signal
transduction, cell cycle regulation and apoptosis, including kinases, transcription
factors and hormone receptors. Hsp72 exhibits anti-apoptotic functions; its up-regulation
may be used as a surrogate marker for Hsp90 inhibition.;
UNII : 2E8412Y946;
InChIKey : RVAQIUULWULRNW-UHFFFAOYSA-N;
CAS number : 1143571-94-1;
Molecule name : STA-9090; STA 9090;
Chemical formula : C20H20N4O3;
Codes from synonyms : 240;
Origin ID : C77872;
UMLS CUI : C3467824;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
