NCIt definition : A multi-peptide cancer vaccine with potential immunostimulating and antineoplastic
activities. IMT-1012 immunotherapeutic vaccine contains twelve different synthetic
peptides or tumor associated antigens (TAAs), including cyclin I (CCNI), cyclin-dependent
kinase CDC2, EDDRI and TACE/ADAM17, each of which is involved in a different pathway
associated with tumor growth, survival, and metastasis. Each antigen in the vaccine
elicits a specific cytotoxic T-lymphocyte (CTL) immune response against tumor cells
expressing that antigen. This multi-antigen/multi-pathway targeting strategy provides
broad immunotherapeutic coverage with respect to tumor complexity and heterogeneity
and may result in enhanced vaccine efficacy.;