Preferred Label : Human Monoclonal Antibody B11-hCG Beta Fusion Protein CDX-1307;
NCIt definition : A human monoclonal antibody (B11) directed against the mannose receptor and linked
to the beta-subunit of human chorionic gonadotropin (hCG beta) with potential immunostimulating
and antineoplastic activities. The monoclonal antibody moiety of human monoclonal
antibody B11-hCG beta fusion protein CDX-1307 binds to mannose receptors on antigen
presenting cells (APCs), including human dendritic cells (DCs) and macrophages. Upon
internalization and processing, APCs present the processed hCG beta antigen on their
cell surfaces, which may initiate an antibody-dependent cell-mediated cytotoxicity
(ADCC) response against hCG beta-expressing tumor cells. The tumor-associated antigen
(TAA) hCG beta is selectively overexpressed by a number of tumors including breast,
colorectal, pancreatic, bladder and ovarian tumors; its expression may correlate with
the stage of disease.;
Molecule name : CDX-1307;
Origin ID : C77858;
UMLS CUI : C2697622;
Semantic type(s)
- concept_is_in_subset
- has_target
