Osteosclerotic Multiple Myeloma

Preferred Label : Osteosclerotic Multiple Myeloma;

NCIt synonyms : Osteosclerotic Plasma Cell Myeloma; Osteosclerotic Myeloma;

NCIt definition : Multiple myeloma associated with osteosclerotic and fibrotic changes in the bone trabeculae. Often, the lymph nodes show changes resembling the plasma cell variant of Castleman disease. It is often part of POEMS syndrome which is characterized by polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes.;

Neoplastic status : Malignant;

Details

Origin ID

C7765;

UMLS CUI

C3898068;

Currated CISMeF NLP mapping
- Osteosclerotic myeloma (disorder) [SNOMED CT concept]
- POEMS syndrome [ORDO Disease]
- osteosclerotic myeloma [DO Concept]
Disease excludes abnormal cell
- Neoplastic T-Lymphocyte and Neoplastic Natural Killer Cell [NCIt concept]
Disease excludes normal cell origin
- Myeloid Cell [NCIt concept]
- Precursor B-Lymphoblast [NCIt concept]
Disease may have findings
- Erectile Dysfunction [NCIt concept]
- Thrombocytosis [NCIt concept]
Has associated anatomic sites
- Hematopoietic System [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
See also inter- (CISMeF)
- POEMS syndrome [Disease (Nov.)]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
concept_is_in_subset
- NCIt Neoplasm Core Terminology [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Localized Lesion [NCIt concept]
disease_has_abnormal_cell
- Abnormal Lymphocyte [NCIt concept]
- Malignant Cell [NCIt concept]
- Neoplastic B-Lymphocyte [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Hematopoietic and Lymphoid Cell [NCIt concept]
- Neoplastic Lymphocyte [NCIt concept]
- Neoplastic Plasma Cell [NCIt concept]
disease_has_finding
- Aberrant Clonal Plasma Cell Population [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Monoclonal Gammopathy [NCIt concept]
- Neoplastic Plasma Cells Present in Bone Marrow [NCIt concept]
- Osteosclerotic Lesion [NCIt concept]
disease_has_molecular_abnormality
- Clonal Immunoglobulin Gene Rearrangement [NCIt concept]
disease_has_normal_cell_origin
- B-Lymphocyte [NCIt concept]
- Bone Marrow-Homing Plasma Cell [NCIt concept]
- Hematopoietic and Lymphoid Cell [NCIt concept]
- Lymphocyte [NCIt concept]
- Mature B-Lymphocyte [NCIt concept]
- Plasma Cell [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic and Lymphoid Tissue [NCIt concept]
- Lymphoid Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Hematopoietic and Lymphatic System [NCIt concept]
- Lymphatic System [NCIt concept]
disease_may_have_associated_disease
- Castleman Disease, Plasma Cell Type [NCIt concept]
- Diabetes Mellitus [NCIt concept]
- Gynecomastia [NCIt concept]
- Hepatomegaly [NCIt concept]
- POEMS Syndrome [NCIt concept]
- Polyneuropathy [NCIt concept]
- Skin Pigmentation Disorder [NCIt concept]
- Splenomegaly [NCIt concept]
disease_may_have_cytogenetic_abnormality
- t(11;14)(q13;q32) [NCIt concept]

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