NCIt definition : The maleate salt form of prochlorperazine, a synthetic, piperazine phenothiazine derivative
with antiemetic, antipsychotic, antihistaminic, and anticholinergic activities. Prochlorperazine
binds to and blocks the postsynaptic dopamine D2-receptor in the chemoreceptor trigger
zone (CTZ) of the brain and may prevent chemotherapy-induced emesis. Prochlorperazine
maleate also blocks anticholinergic and alpha-adrenergic receptors. Its antagonistic
actions on the alpha-1 adrenergic receptors results in sedation, muscle relaxation,
and hypotension.;