Ketotrexate - CISMeF

Preferred Label : Ketotrexate;

NCIt definition : A folic acid antagonist and mammalian dihydrofolate reductase inhibitor with antineoplastic activity. Ketotrexate inhibits dihydrofolate reductase, an enzyme that reduces dihydrofolic acid to tetrahydrofolic acid which is essential for the synthesis of purine nucleotides and thymidylate. By depleting tetrahydrofolic acid availability, DNA synthesis is halted.;

UNII : 504RN634MM;

InChIKey : KCPBTDJBDDCNQE-KZUDCZAMSA-N;

CAS number : 52196-22-2;

Chemical formula : C21H27N7O6;

Details

Origin ID

C77403;

UMLS CUI

C2697842;

Automatic exact mappings (from CISMeF team)
- 5-methyltetrahydrohomofolic acid [MeSH Supplementary Concept]
- 5-methyltetrahydrohomofolic acid [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_salt_form
- Ketotrexate Disodium [NCIt concept]
is_free_acid_or_base_form_of
- Ketotrexate Disodium [NCIt concept]

Keyword's position in hierarchy(ies) :

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