Preferred Label : Ketotrexate;
NCIt definition : A folic acid antagonist and mammalian dihydrofolate reductase inhibitor with antineoplastic
activity. Ketotrexate inhibits dihydrofolate reductase, an enzyme that reduces dihydrofolic
acid to tetrahydrofolic acid which is essential for the synthesis of purine nucleotides
and thymidylate. By depleting tetrahydrofolic acid availability, DNA synthesis is
halted.;
UNII : 504RN634MM;
InChIKey : KCPBTDJBDDCNQE-KZUDCZAMSA-N;
CAS number : 877017-93-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 877017-93-1
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G-SRS /a ;
Chemical formula : C21H27N7O6;
Origin ID : C77403;
UMLS CUI : C2697842;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- concept_is_in_subset
