Ketotrexate Disodium

Preferred Label : Ketotrexate Disodium;

NCIt synonyms : Methyltetrahydrohomofolate; MeTHHF Disodium; Emfolin Sodium; 5-Methyltetrahydrohomofolate Disodium; Emofolin Sodium;

NCIt definition : The sodium salt of ketotrexate, a synthetic antimetabolite analogue of folate with antineoplastic activity. Upon administration, ketotrexate competes for the folate binding site of the enzyme dihydrofolate reductase, resulting in inhibition of tetrahydrofolate synthesis, depletion of nucleotide pools, and inhibition of DNA, RNA and protein synthesis. (NCI04);

UNII : 129MT3SP3E;

CAS number : 52386-42-2;

NSC code : 139490;

Details

Origin ID

C29019;

UMLS CUI

C0098575;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- 5-methyltetrahydrohomofolate [MeSH concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_free_acid_or_base_form
- Ketotrexate [NCIt concept]
is_salt_form_of
- Ketotrexate [NCIt concept]

Keyword's position in hierarchy(ies) :

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