Preferred Label : Procarbazine Hydrochloride;
NCIt synonyms : PCB; N-4-isopropylcarbamoylbenzyl-N'-methylhydrazine Hydrochloride; p-toluamide, N-isopropyl-alpha-(2-methylhydrazino)-, monohydrochloride (8CI); MIH hydrochloride; p-(N'-methylhydrazinomethyl)-N-isopropylbenzamide hydrochloride; N-isopropyl-alpha-(2-methylhydrazino)-p-toluamide Hydrochloride; N-(1-methylethyl)-4-[(2-methylhydrazino)methyl]benzamide Hydrochloride; PCZ; benzamide, N-(1-methylethyl)-4-[(2-methylhydrazino) methyl]-, monohydrochloride (9CI); Procarbazine;
NCIt related terms : Natunalar; Matulane; Ro 4 6467/1; p-Toluamide, N-isopropyl-.alpha.-(2-methylhydrazino)-, monohydrochloride (8CI); NCI-C01810; PCB hydrochloride; Natulan; Ibenzmethyzine hydrochloride;
NCIt definition : The hydrochloride salt of a methylhydrazine derivative with antineoplastic and mutagenic
activities. Although the exact mode of cytotoxicity has not been elucidated, procarbazine,
after metabolic activation, appears to inhibit the trans-methylation of methionine
into transfer RNA (t-RNA), thereby preventing protein synthesis and consequently DNA
and RNA synthesis. This agent may also undergo auto-oxidation, resulting in the formation
of cytotoxic free radicals which damage DNA through an alkylation reaction.;
Alternative definition : NCI-GLOSS: A drug that is used to treat advanced Hodgkin lymphoma and is being studied
in the treatment of other types of cancer. Matulane blocks cells from making proteins
and damages DNA. It may kill cancer cells. It is a type of antineoplastic agent and
a type of alkylating agent.;
UNII : XH0NPH5ZX8;
InChIKey : DERJYEZSLHIUKF-UHFFFAOYSA-N;
CAS number : 366-70-1;
Drug name : Natulan; Matulane; Natulanar; Natunalar;
Molecule name : Ro 4-6467/1; NCI-C01810; NCI C01810;
Chemical formula : C12H19N3O.HCl;
NSC code : 77213;
Codes from synonyms : CDR0000635747; CDR0000635746; NSC0077213;
Origin ID : C773;
UMLS CUI : C0205909;
False automatic mappings
- See also inter- (CISMeF)
- Semantic type(s)
- Validated automatic mappings to NTBT
- concept_is_in_subset
- has_free_acid_or_base_form
- is_component_of_chemotherapy_regimen
- is_salt_form_of
