Procarbazine - CISMeF

Preferred Label : Procarbazine;

NCIt synonyms : N-Methylhydrazine; N-4-isopropylcarbamoylbenzyl-N'-methylhydrazine; Benzethyzin; Procarbazin; N-isopropyl-alpha-(2-methylhydrazino)-p-toluamide; Ibenzmethyzin; N-(1-methylethyl)-4-[(2-methylhydrazino)methyl]benzamide; p-(N'-methylhydrazinomethyl)-N-isopropylbenzamide; Procarbazine Base;

NCIt definition : A methylhydrazine derivative with antineoplastic and mutagenic activities. Although the exact mode of cytotoxicity has not been elucidated, procarbazine, after metabolic activation, appears to inhibit the trans-methylation of methionine into transfer RNA (t-RNA), thereby preventing protein synthesis and consequently DNA and RNA synthesis. This agent may also undergo auto-oxidation, resulting in the formation of cytotoxic free radicals which damage DNA through an alkylation reaction.;

Alternative definition : NCI-GLOSS: The active ingredient in a drug that is used to treat advanced Hodgkin lymphoma and is being studied in the treatment of other types of cancer. Procarbazine blocks cells from making proteins and damages DNA. It may kill cancer cells. It is a type of antineoplastic agent and a type of alkylating agent.;

UNII : 35S93Y190K;

InChIKey : CPTBDICYNRMXFX-UHFFFAOYSA-N;

CAS number : 671-16-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 671-16-9 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Chemical formula : C12H19N3O;

Codes from synonyms : CDR0000045378; 419;

Details

Origin ID

C62072;

UMLS CUI

C0033223;

Automatic exact mappings (from CISMeF team)
- Procarbazine [ICHI extension code]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Procarbazine [ICD-11 Extension code]
- Procarbazine (substance) [SNOMED CT concept]
- Product containing procarbazine (medicinal product) [SNOMED CT concept]
- procarbazine [ATC Code]
- procarbazine [Substance BNPC]
- procarbazine [MeSH Descriptor]
- procarbazine [MeSH concept]
- procarbazine [SNOMED Notion]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HL Authorized Value Terminology [NCIt concept]
- HL Protocol Treatment Modifications Table [NCIt concept]
- HL Total Dose Table [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_salt_form
- Procarbazine Hydrochloride [NCIt concept]
is_component_of_chemotherapy_regimen
- MPV Regimen [NCIt concept]
- R-MPV Regimen [NCIt concept]
is_free_acid_or_base_form_of
- Procarbazine Hydrochloride [NCIt concept]

Keyword's position in hierarchy(ies) :

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