Preferred Label : Linaclotide Acetate;
NCIt synonyms : L-Tyrosine, L-cysteinyl-L-cysteinyl-L-alpha-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-,
cyclic (1- 6),(2- 10),(5- 13)-tris(disulfide), Monoacetate (salt);
NCIt definition : The acetate salt form of linaclotide, a synthetic, fourteen amino acid peptide and
agonist of intestinal guanylate cyclase type C (GC-C), which is structurally related
to the guanylin peptide family, with secretagogue, analgesic and laxative activities.
Upon oral administration, linaclotide binds to and activates GC-C receptors located
on the luminal surface of the intestinal epithelium. This increases the concentration
of intracellular cyclic guanosine monophosphate (cGMP), which is derived from guanosine
triphosphate (GTP). cGMP activates the cystic fibrosis transmembrane conductance regulator
(CFTR) and stimulates the secretion of chloride and bicarbonate into the intestinal
lumen. This promotes sodium excretion into the lumen and results in increased intestinal
fluid secretion. This ultimately accelerates GI transit of intestinal contents, improves
bowel movement and relieves constipation. Increased extracellular cGMP levels may
also exert an antinociceptive effect, through an as of yet not fully elucidated mechanism,
that may involve modulation of nociceptors found on colonic afferent pain fibers.
Linaclotide is minimally absorbed from the GI tract.;
UNII : NSF067KU1M;
CAS number : 851199-60-5;
Molecule name : MM-416775; MD-1100 Acetate;
Chemical formula : C59H79N15O21S6.C2H4O2;
Origin ID : C77223;
UMLS CUI : C2697923;
Currated CISMeF NLP mapping
- Manual NTBT mappings (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to NTBT
- concept_is_in_subset
- has_free_acid_or_base_form
- is_salt_form_of
