Preferred Label : Tolvaptan;
NCIt synonyms : 7-Chloro-5-hydroxy-1-(2-methyl-4-(2-methylbenzoylamino)benzoyl)2,3,4,5-tetrahydro-1H-1-benzazepine; N-(4-{[(5R)-7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]carbonyl}-3-methylphenyl)-2-methylbenzamide;
NCIt definition : An orally bioavailable, selective, arginine vasopressin receptor 2 (V2, AVPR2) antagonist
that can be used to treat hyponatremia. Upon oral administration, tolvaptan selectively
and competitively binds to and blocks the V2 receptor located in the walls of the
vasculature and luminal membranes of renal collecting ducts, thereby preventing the
binding of vasopressin to the V2 receptor. This prevents water absorption in the kidneys
and increases the excretion of electrolyte-free water via the kidneys. This reduces
intravascular volume and increases serum sodium concentrations and osmolality.;
UNII : 21G72T1950;
InChIKey : GYHCTFXIZSNGJT-UHFFFAOYSA-N;
CAS number : 150683-30-0;
Drug name : Samsca;
Molecule name : OPC-41061;
Chemical formula : C26H25ClN2O3;
Origin ID : C77082;
UMLS CUI : C1176308;
Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
- has_target
