Denibulin - CISMeF

Preferred Label : Denibulin;

NCIt definition : A small molecular vascular disrupting agent (VDA), with potential antimitotic and antineoplastic activities. Denibulin selectively targets and reversibly binds to the colchicine-binding site on tubulin and inhibits microtubule assembly. This results in the disruption of the cytoskeleton of tumor endothelial cells, ultimately leading to cell cycle arrest, blockage of cell division and apoptosis. This causes inadequate blood flow to the tumor and eventually leads to a decrease in tumor cell proliferation.;

UNII : K7037M241U;

InChIKey : GAOHLWCIAJNSEE-JTQLQIEISA-N;

CAS number : 284019-34-7;

Chemical formula : C18H19N5O3S;

Details

Origin ID

C77065;

UMLS CUI

C2699587;

Automatic exact mappings (from CISMeF team)
- MN-029 [MeSH concept]
- denibulin [MeSH Supplementary Concept]
Currated CISMeF NLP mapping
- denibulin [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- denibulin [MeSH Supplementary Concept]
- denibulin [MeSH concept]
chemical_or_drug_has_mechanism_of_action
- Microtubule Process [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_salt_form
- Denibulin Hydrochloride [NCIt concept]
is_free_acid_or_base_form_of
- Denibulin Hydrochloride [NCIt concept]

Keyword's position in hierarchy(ies) :

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