NCIt definition : A small molecular vascular disrupting agent (VDA), with potential antimitotic and
antineoplastic activities. Denibulin selectively targets and reversibly binds to the
colchicine-binding site on tubulin and inhibits microtubule assembly. This results
in the disruption of the cytoskeleton of tumor endothelial cells, ultimately leading
to cell cycle arrest, blockage of cell division and apoptosis. This causes inadequate
blood flow to the tumor and eventually leads to a decrease in tumor cell proliferation.;
UNII : K7037M241U;
InChIKey : GAOHLWCIAJNSEE-JTQLQIEISA-N;
CAS number : 284019-34-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 284019-34-7
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