" /> Denibulin Hydrochloride - CISMeF





Preferred Label : Denibulin Hydrochloride;

NCIt definition : The hydrochloride salt of denibulin, a small molecular vascular disrupting agent, with potential antimitotic and antineoplastic activities. Denibulin selectively targets and reversibly binds to the colchicine-binding site on tubulin and inhibits microtubule assembly. This results in the disruption of the cytoskeleton of tumor endothelial cells, ultimately leading to cell cycle arrest, blockage of cell division and apoptosis. This causes inadequate blood flow to the tumor and eventually leads to a decrease in tumor cell proliferation., a small molecule vascular disrupting agent (VDA), with potential antimitotic and antineoplastic activity. Denibulin selectively targets and reversibly binds to the colchicine-binding site on tubulin and inhibits microtubule assembly. This results in the disruption of the cytoskeleton of tumor endothelial cells (EC), ultimately leading to cell cycle arrest, blockage of cell division and apoptosis. This causes inadequate blood flow to the tumor and eventually leads to a decrease in tumor cell proliferation.;

UNII : 0U575HR16Q;

InChIKey : JUMSCXLBFWHCRA-PPHPATTJSA-N;

CAS number : 779356-64-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 779356-64-8 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : MN-029;

Chemical formula : C18H19N5O3S.HCl;

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16/05/2024


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