Preferred Label : Fluticasone Furoate;
NCIt definition : The furoate salt form of fluticasone, a synthetic trifluorinated glucocorticoid receptor
agonist with anti-allergic, anti-inflammatory and anti-pruritic effects. Upon administration,
fluticasone binds to and activates glucocorticoid receptor, resulting in the activation
of lipocortin. Lipocortin, in turn, inhibits cytosolic phospholipase A2 and the cascade
of reactions involved in the synthesis of inflammatory mediators, such as prostaglandins
and leukotrienes. Secondly, mitogen-activated protein kinase (MAPK) phosphatase 1
is induced, which leads to dephosphorylation and inactivation of Jun N-terminal kinase
and directly inhibits c-Jun mediated transcription. Finally, transcriptional activity
of nuclear factor (NF)-kappa-B is blocked, thereby inhibiting the transcription of
cyclooxygenase 2 (COX-2), which is essential for prostaglandin production.;
UNII : JS86977WNV;
InChIKey : XTULMSXFIHGYFS-VLSRWLAYSA-N;
CAS number : 397864-44-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 397864-44-7
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G-SRS /a ;
Chemical formula : C27H29F3O6S;
Origin ID : C77003;
UMLS CUI : C1948374;
Automatic exact mappings (from CISMeF team)
- CISMeF manual mappings
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- chemical_or_drug_is_metabolized_by_enzyme
- concept_is_in_subset
