Carglumic Acid

Preferred Label : Carglumic Acid;

NCIt synonyms : N-Carbamylglutamate;

NCIt definition : An orally active, synthetic structural analogue of N-acetylglutamate (NAG) and carbamoyl phosphate synthetase 1 (CPS 1) activator, with ammonia lowering activity. NAG, which is formed by the hepatic enzyme N-acetylglutamate synthase (NAGS), is an essential allosteric activator of the enzyme carbamoyl phosphate synthetase 1 (CPS 1). CPS 1 plays an essential role in the urea cycle and converts ammonia into urea. Upon oral administration, carglumic acid can replace NAG in NAGS deficient patients and activates CPS 1, which prevents hyperammonaemia.;

UNII : 5L0HB4V1EW;

InChIKey : LCQLHJZYVOQKHU-VKHMYHEASA-N;

CAS number : 1188-38-1;

Drug name : Carbaglu;

Molecule name : OE 312;

Chemical formula : C6H10N2O5;

PubMed : 18516804;

Details

Origin ID

C76884;

UMLS CUI

C1318649;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Carglumic acid (substance) [SNOMED CT concept]
- Product containing carglumic acid (medicinal product) [SNOMED CT concept]
- carglumic acid [ATC Code]
- carglumic acid [International Nonproprietary Name]
- carglumic acid [MeSH concept]
- carglumic acid [MeSH Supplementary Concept]
Validated automatic mappings to BTNT
- carglumic acid [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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