Amotosalen - CISMeF

Preferred Label : Amotosalen;

NCIt definition : A synthetic psoralen, light-activated DNA and RNA crosslinking agent, with protective activity against pathogens such as bacteria, viruses, protozoa, and leukocytes. Prior to administration amotosalen is added to plasma and platelets, then in vivo this agent penetrates pathogens and targets DNA and RNA. Upon activation by ultraviolet A light, this agent is able to form interstrand DNA and RNA crosslinks and prevents replication. Inactivation of leukocytes can prevent graft versus host disease upon transfusion.;

UNII : K1LDZ0VBC0;

InChIKey : FERWCFYKULABCE-UHFFFAOYSA-N;

CAS number : 161262-29-9;

Chemical formula : C17H19NO4;

Details

Origin ID

C76756;

UMLS CUI

C1136704;

Automatic exact mappings (from CISMeF team)
- amotosalen-HCl [Blood Transfusion thesaurus concept]
Currated CISMeF NLP mapping
- amotosalen [MeSH concept]
- amotosalen [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- amotosalen [MeSH Supplementary Concept]
- amotosalen [MeSH concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_salt_form
- Amotosalen Hydrochloride [NCIt concept]
is_free_acid_or_base_form_of
- Amotosalen Hydrochloride [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients