Amotosalen Hydrochloride

Preferred Label : Amotosalen Hydrochloride;

NCIt definition : The hydrochloride salt form of amotosalen, a synthetic psoralen and light-activated DNA, RNA crosslinking agent, with protective activity against pathogens such as bacteria, viruses, protozoa, and leukocytes. Prior to administration amotosalen is added to plasma and platelets, then in vivo the agent penetrates pathogens and targets DNA and RNA. Upon activation by ultraviolet A light, this agent is able to form interstrand DNA and RNA crosslinks and prevents replication. Inactivation of leukocytes can prevent graft versus host disease upon transfusion.;

UNII : 67B255SI5F;

InChIKey : MHLAMQBABOJZQW-UHFFFAOYSA-N;

CAS number : 161262-45-9;

Chemical formula : C17H19NO4.ClH;

Détails

Origin ID

C72699;

UMLS CUI

C2346748;

Automatic exact mappings (from CISMeF team)
- amotosalen-HCl [Blood Transfusion thesaurus concept]
Currated CISMeF NLP mapping
- amotosalen hydrochloride [MeSH concept]
Semantic type(s)
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- amotosalen hydrochloride [MeSH concept]
Validated automatic mappings to NTBT
- amotosalen [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_free_acid_or_base_form
- Amotosalen [NCIt concept]
is_salt_form_of
- Amotosalen [NCIt concept]

Position du mot-clé dans l'(les) arborescence(s) :

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