Tirofiban - CISMeF

Preferred Label : Tirofiban;

NCIt definition : A non-peptide tyrosine derivative, with anticoagulant activity. Upon administration, tirofiban antagonizes fibrinogen binding to the platelet cell surface receptor, glycoprotein (GP) IIb/IIIA complex, one of the two purinergic receptors activated by ADP. This prevents the GP IIb/IIIa receptor complex-mediated activation of adenylyl cyclase. This results in decreased levels of cAMP, interferes with the platelet membrane function and subsequent platelet-platelet interaction, prevents the release of platelet granule constituents and prolongs bleeding time.;

UNII : GGX234SI5H;

InChIKey : COKMIXFXJJXBQG-NRFANRHFSA-N;

CAS number : 144494-65-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 144494-65-5 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Chemical formula : C22H36N2O5S;

ChEBI ID : CHEBI:9605;

Codes from synonyms : 497;

Details

Origin ID

C76405;

UMLS CUI

C0247025;

Automatic exact mappings (from CISMeF team)
- Tirofiban [ICD-11 Extension code]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing tirofiban (medicinal product) [SNOMED CT concept]
- Tirofiban [MeSH Descriptor]
- Tirofiban [LOINC component]
- Tirofiban (substance) [SNOMED CT concept]
- tirofiban [ATC Code]
- tirofiban [MeSH concept]
Validated automatic mappings to BTNT
- tirofiban [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
has_salt_form
- Tirofiban Hydrochloride [NCIt concept]
is_free_acid_or_base_form_of
- Tirofiban Hydrochloride [NCIt concept]

Keyword's position in hierarchy(ies) :

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