Vinflunine Ditartrate

Preferred Label : Vinflunine Ditartrate;

NCIt related terms : Javlor;

NCIt definition : The ditartrate salt of vinflunine, a bi-fluorinated derivative of the semisynthetic vinca alkaloid vinorelbine with potential antimitotic and antineoplastic activities. Vinflunine binds to tubulin and inhibits tubulin assembly and disrupts microtubule assembly dynamics. This results in cell cycle arrest in mitosis and an induction of apoptosis.;

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of bladder cancer, lung cancer, and other types of cancer.;

UNII : 33MG53C7XW;

InChIKey : YIHUEPHBPPAAHH-IIQAEXPMSA-N;

CAS number : 194468-36-5;

Chemical formula : C45H54F2N4O8.2C4H6O6;

Codes from synonyms : CDR0000512884;

Details

Origin ID

C76266;

UMLS CUI

C2700251;

Automatic exact mappings (from CISMeF team)
- javlor [MeSH concept]
Manual NTBT mappings (CISMeF)
- Vinflunine (substance) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
Validated automatic mappings to NTBT
- vinflunine [MeSH Supplementary Concept]
chemical_or_drug_has_mechanism_of_action
- Microtubule Process [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_free_acid_or_base_form
- Vinflunine [NCIt concept]
is_salt_form_of
- Vinflunine [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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