" /> Zosuquidar - CISMeF





Preferred Label : Zosuquidar;

NCIt synonyms : (R)-4-((1aR,6R,10bS)-1,2-Difluoro-1,1a,6,10b-tetrahydrodibenzo(a,e)cyclopropa(c)cycloheptan-6-yl)-alpha-((5-quinoloyloxy)methyl)-1-piperazineethanol;

NCIt definition : A difluorocyclopropyl quinoline. Zosuquidar binds with high affinity to P-glycoprotein and inhibits P-glycoprotein-mediated multidrug resistance (MDR). P-glycoprotein, encoded by the MDR-1 gene, is a member of the ATP-binding cassette superfamily of transmembrane transporters and prevents the intracellular accumulation of many natural product-derived cytotoxic agents.;

UNII : AB5K82X98Y;

InChIKey : IHOVFYSQUDPMCN-DBEBIPAYSA-N;

CAS number : 167354-41-8;

Chemical formula : C32H31F2N3O2;

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Keyword's position in hierarchy(ies) : arborescence

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09/05/2025


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