Preferred Label : Zosuquidar Trihydrochloride;
NCIt synonyms : (R)-4-((1aR,6R,10bS)-1,2-Difluoro-1,1a,6,10b-tetrahydrodibenzo(a,e)cyclopropa(c)cycloheptan-6-yl)-alpha-((5-quinoloyloxy)methyl)-1-piperazineethanol,
Trihydrochloride;
NCIt related terms : LY335979;
NCIt definition : A difluorocyclopropyl quinoline. Zosuquidar trihydrochloride binds with high affinity
to P-glycoprotein and inhibits P-glycoprotein-mediated multidrug resistance (MDR).
P-glycoprotein, encoded by the MDR-1 gene, is a member of the ATP-binding cassette
superfamily of transmembrane transporters and prevents the intracellular accumulation
of many natural product-derived cytotoxic agents. (NCI04);
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of cancer. Zosuquidar trihydrochloride
may help kill cancer cells that are resistant to anticancer drugs.;
UNII : 813AGY3126;
InChIKey : ZPFVQKPWGDRLHL-WITOOOCMSA-N;
CAS number : 167465-36-3;
Molecule name : LY335979;
Chemical formula : C32H31F2N3O2.3ClH;
NSC code : 725086;
Codes from synonyms : CDR0000257971; CDR0000046762;
Origin ID : C2225;
UMLS CUI : C0528372;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_free_acid_or_base_form
- is_component_of_chemotherapy_regimen
- is_salt_form_of
