Hydroxyproline

Preferred Label : Hydroxyproline;

NCIt synonyms : 4-Hydroxy-L-proline;

NCIt definition : A nonessential amino acid derivative formed during post-translational protein modification through hydroxylation of the amino acid proline by the enzyme prolyl hydroxylase which requires vitamin C as a co-factor. Hydroxyproline is a major component of the protein collagen and plays a key role in the stability of the collagen triple helix. It can be used as an indicator to determine the amount of collagen. Increased hydroxyproline levels in the urine and/or serum are normally associated with degradation of connective tissue. Vitamin C deficiency decreases the conversion of proline to hydroxyproline, which leads to reduced collagen stability.;

UNII : RMB44WO89X;

InChIKey : PMMYEEVYMWASQN-DMTCNVIQSA-N;

CAS number : 51-35-4;

Unit used : g;

Chemical formula : C5H9NO3;

NSC code : 46704;

ChEBI ID : CHEBI:18240; CHEBI:18095;

Details

Origin ID

C76144;

UMLS CUI

C0020388;

Currated CISMeF NLP mapping
- Hydroxyproline [LOINC component]
- Hydroxyproline [MedDRA Preferred Term]
- Hydroxyproline (substance) [SNOMED CT concept]
- hydroxyproline [Substance BNPC]
- hydroxyproline [MeSH Descriptor]
- hydroxyproline [MeSH concept]
- hydroxyproline, nos [SNOMED Notion]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Hydroxyproline [LOINC component]
- Hydroxyproline (substance) [SNOMED CT concept]
- L-Hydroxyproline (substance) [Inactive SNOMED CT concept]
- hydroxyproline [MeSH concept]
- hydroxyproline [MeSH Descriptor]
- hydroxyproline, nos [SNOMED Notion]
- trans-4-hydroxy-L-proline [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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