Delapril - CISMeF

Preferred Label : Delapril;

NCIt definition : A lipophilic, non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, delapril is converted to two active metabolites, delapril diacid and 5-hydroxy delapril diacid, which competitively bind to and inhibit ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Delapril also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.;

UNII : W77UAL9THI;

InChIKey : WOUOLAUOZXOLJQ-MBSDFSHPSA-N;

CAS number : 83435-66-9;

Chemical formula : C26H32N2O5;

Details

Origin ID

C75022;

UMLS CUI

C0057301;

CISMeF manual mappings
- Delapril (substance) [SNOMED CT concept]
Currated CISMeF NLP mapping
- delapril [MeSH concept]
- delapril [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Delapril (substance) [SNOMED CT concept]
- delapril [ATC Code]
- delapril [MeSH concept]
- delapril [MeSH Supplementary Concept]
Validated automatic mappings to BTNT
- delapril [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_salt_form
- Delapril Hydrochloride [NCIt concept]
is_free_acid_or_base_form_of
- Delapril Hydrochloride [NCIt concept]

Keyword's position in hierarchy(ies) :

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