" /> Delapril Hydrochloride - CISMeF





Preferred Label : Delapril Hydrochloride;

NCIt definition : The hydrochloride salt of delapril, a lipophilic, non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, delapril is converted to two active metabolites, delapril diacid and 5-hydroxy delapril diacid, which competitively bind to and inhibit ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Delapril also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.;

UNII : 2SMM3M5ZMH;

InChIKey : FDJCVHVKXFIEPJ-JCNFZFLDSA-N;

CAS number : 83435-67-0;

Chemical formula : C26H32N2O5.HCl;

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08/05/2025


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