Esorubicin Hydrochloride

Preferred Label : Esorubicin Hydrochloride;

NCIt synonyms : 4'-Deoxyadriamycin HCl; 4'-Deoxydoxorubicin HCl; (2S-(2alpha(8R*,10R*),4beta,6beta))-10-((4-Aminotetrahydro-6-methyl-2H-pyran-2-yl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacene-5,12-dione Hydrochloride; Deoxydoxorubicin HCI;

NCIt definition : A hydrochloride salt of esorubicin, a derivative of the anthracycline antineoplastic antibiotic doxorubicin, with potential antineoplastic activity. Esorubicin intercalates into DNA and inhibits topoisomerase II, thereby inhibiting DNA replication and ultimately, interfering with RNA and protein synthesis. This agent exhibits less cardiotoxicity than the parent antibiotic doxorubicin, but may cause more severe myelosupression compared to other compounds within the anthracycline class.;

UNII : 2UB1JJT82D;

InChIKey : RCFNNLSZHVHCEK-YGCMNLPTSA-N;

CAS number : 63950-06-1;

Chemical formula : C27H29NO10.HCl;

Details

Origin ID

C74943;

UMLS CUI

C0955070;

Semantic type(s)
- Antibiotic [UMLS semantic type]
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
UMLS correspondences (same concept)
- 4'-deoxydoxorubicin hydrochloride [MeSH concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_free_acid_or_base_form
- Esorubicin [NCIt concept]
is_salt_form_of
- Esorubicin [NCIt concept]

Keyword's position in hierarchy(ies) :

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