NCIt definition : The hydrochloride salt of a natural alkaloid extracted from plants of the genus Pilocarpus
with cholinergic agonist activity. As a cholinergic parasympathomimetic agent, pilocarpine
predominantly binds to muscarinic receptors, thereby inducing exocrine gland secretion
and stimulating smooth muscle in the bronchi, urinary tract, biliary tract, and intestinal
tract. When applied topically to the eye, this agent stimulates the sphincter pupillae
to contract, resulting in miosis; stimulates the ciliary muscle to contract, resulting
in spasm of accomodation; and may cause a transitory rise in intraocular pressure
followed by a more persistent fall due to opening of the trabecular meshwork and an
increase in the outflow of aqueous humor.;