Rebemadlin - CISMeF

Preferred Label : Rebemadlin;

NCIt synonyms : Nutlin-3a;

NCIt definition : A small molecule and MDM2 (murine double minute 2) inhibitor, with potential antineoplastic activity. In cancer cells, rebemadlin antagonizes the binding of MDM2 to p53, thereby preventing MDM2-mediated p53 degradation. This results in stabilizing and activating p53-dependent cell cycle arrest and apoptosis. The protein MDM2, a negative regulator of p53 activity, is overexpressed in many cancer cell types; the tumor suppressor p53 is mutated or deleted in about 50% of all cancers but active in the other 50%.;

UNII : L7C92IOE65;

CAS number : 675576-98-4;

Molecule name : SML-0580;

Details

Origin ID

C74594;

UMLS CUI

C1956368;

Currated CISMeF NLP mapping
- nutlin-3A [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- nutlin-3A [MeSH concept]
chemical_or_drug_has_physiologic_effect
- Positive Regulation of Apoptosis [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- E3 Ubiquitin-Protein Ligase MDM2 [NCIt concept]

Keyword's position in hierarchy(ies) :

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