NCIt definition : A small molecule and MDM2 (murine double minute 2) inhibitor, with potential antineoplastic
activity. In cancer cells, rebemadlin antagonizes the binding of MDM2 to p53, thereby
preventing MDM2-mediated p53 degradation. This results in stabilizing and activating
p53-dependent cell cycle arrest and apoptosis. The protein MDM2, a negative regulator
of p53 activity, is overexpressed in many cancer cell types; the tumor suppressor
p53 is mutated or deleted in about 50% of all cancers but active in the other 50%.;
UNII : L7C92IOE65;
CAS number : 675576-98-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 675576-98-4
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