Aminopterin Sodium

Preferred Label : Aminopterin Sodium;

NCIt synonyms : Sodium Aminopterin;

NCIt definition : The sodium salt of a pterin derivative with antineoplastic and immunosuppressive properties. As a folate analogue, aminopterin competes for the folate binding site of the enzyme dihydrofolate reductase, thereby blocking tetrahydrofolate synthesis, and resulting in depletion of nucleotide precursors and inhibition of DNA, RNA and protein synthesis. (NCI04);

UNII : FZU1QI13O9;

CAS number : 58602-66-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 58602-66-7 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Chemical formula : C19H18N8O5.2Na;

Details

Origin ID

C74554;

UMLS CUI

C0282048;

Automatic exact mappings (from CISMeF team)
- Aminopterin sodium [ICHI extension code]
- Sodium aminopterin [ICHI extension code]
- aminopterin [MeSH Descriptor]
Currated CISMeF NLP mapping
- Aminopterin sodium [ICD-11 Extension code]
- Sodium aminopterin [ICD-11 Extension code]
- aminopterin sodium [MeSH concept]
Semantic type(s)
- Hazardous or Poisonous Substance [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Aminopterin sodium [ICD-11 Extension code]
- Sodium aminopterin [ICD-11 Extension code]
- aminopterin sodium [MeSH concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_free_acid_or_base_form
- Aminopterin [NCIt concept]
is_salt_form_of
- Aminopterin [NCIt concept]

Keyword's position in hierarchy(ies) :

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